Anti-neoplastic drug

ABSTRACT

A unique class of anti-neoplastic compositions are described. The compositions contain certain Chinese medicinal herbs:  Panax ginsing, Poria cocos, Atractylodes macrocephala, Angelic sinensis, Astragalus membranaceus, Curcuma zedoaria, Scutellaria baicalensis, Coptis chinenisis, Glycyrrhiza uralenisis, Crataegus pinatifida, Hordeum vulgare, Schisandra chinensis, Hedyotis diffusa, Ophiophogon japonicus , and  Lobelia chinesis lour . Extensive testing indicates an effective treatment rate of 69.7% and 84.3% when used in combination with radiotherapy or chemotherapy. The animal trials conducted demonstrate that the anti-neoplastic compositions increase the activity of NK cells, and reduce and prevent metastasis of tumors under stress conditions.

FIELD OF THE INVENTION

The present invention relates to compositions for treatment of cancerand specifically, tumors. More particularly, the present invention isdirected to anti-neoplastic compositions comprising a particularcombination of herbs.

BACKGROUND OF THE INVENTION

According to the data released by the Ministry of Public Health ofChina, cancer was ranked as the number one cause of death in urban areasof China in 1990. More than one million patients die from cancer everyyear in mainland China. In the United States, one person dies fromcancer every minute. And in the United States, there are 3 millioncancer patients, one-third of which will eventually die from thisdisease. At present, more than 100 different types of cancer have beenidentified.

Although operation, radiotherapy and chemotherapy are used as the maintherapeutics, it is well known that the treatment of middle and latestage cancer is very difficult. There are many patients whose cancer hasprogressed such that they are inoperable. Furthermore, chemotherapy andradiotherapy do not always result in the desired effect. Moreover, thesetreatment strategies have serious side effects, including weakness,anorexia, loss of hair, inhibition of the function of bone marrowhematopoiesis, impairment of liver and kidney and ovary function, etc.After such treatments, patients often relapse because the immune systemis extremely suppressed, typically for ten hours after operation. It istherefore pertinent that a new therapeutic strategy is identified toenhance cancer treatment as well as reduce the side effects ofoperation, chemotherapy and radiotherapy.

Traditional Chinese medicine has been used clinically for more than 3000years. As a result, vast clinical experience has been obtained. Chinesemedicine has provided unexpected and beneficial effects in the treatmentof various diseases, including cancer. However, it was not until thelast three decades that modern scientific methods have been used to testtraditional Chinese medicine and reveal that such medical practicesoften provide remarkable results.

Research and development of anti-cancer drugs from plants have been verybeneficial. Advances in biochemical and pharmacological studies ofplant-derived drugs have resulted in significant impetus on the furtherresearch and development of anti-cancer drugs from plants. However,currently available medicines only emphasize a single aspect of cancertreatment, for example, only for increasing the function of the immunesystem, or only for suppressing tumors, or only for improving bloodcirculation, etc.

Accordingly, there is a need for an improved formulation and methodologyfor treating cancer, and specifically for tumors.

SUMMARY OF THE INVENTION

The objective of the present invention is to provide new anti-cancercompositions that are believed to strengthen the body's resistance andthereby eliminate pathogenic factors. These compositions are believed toincrease the function of the immune system, and impart anti-stress andanti-tumor characteristics to the body. The compositions are furtherbelieved to improve micro-circulation and thereby reverse and destroytumor cells. The clinical trials described herein demonstrate that thenew anti-neoplastic compositions of the present discovery possesssignificant therapeutic efficacy.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 shows the effects of increasing doses of ACNO (low, medium andhigh: 0.1, 0.5 and 2 g/kg/day) on NK activity (% specific killing) inincreasing effector to target (E/T) ratios. ACNO caused a significantdose-dependent increase in NK activity (P<0.0001).

FIG. 2 shows the effects of ACNO (2 g/kg/day) and of β-receptor agonist(MP) (0.8 g/kg body weight) on the cells number of MADB 106 metastases,wherein MP injection significantly increased the cells number ofmetastases, while ACNO administration significantly decreased the cellsnumber of metastases (P<0.0006).

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The various compositions for treatment of cancer and tumors specificallycomprise one or more, or all, of the following Chinese herbal medicines:Red Ginseng (also known as Red Ren Shen) (PANAX GINSING), Fu Ling (PORIACOCOS), Bai Zhu (ATRACTYLODES MACROCEPHALA), Dang Gui (ANGELICSINENSIS), Huang Qi (ASTRAGALUS MEMBRANACEUS), E Zhu (CURCUMA ZEDOARIA),Huang Qin (SCUTELLARIA BAICALENSIS), Huang Lian (COPTIS CHINENSIS),Huang Bai (PHELLODRON CHINENSE), Gan Cao (GLYCYRRHIZA URALENSIS), ShanZha (CRATAEGUS PINATIFIDA), Mai Ya (HORDEUM VULGARE), Dan Shen (SALVIAMILTIORRHIZA), Wu Wei Zi (SCHISANDRA CHINENSIS), Bai Hua She She Cao(HEDYOTIS DIFFUSA), Mai Men Dong (OPHIOPHOGON JAPONICUS), Ban Bian Lian(LOBELIA CHINESIS LOUR), Ban Zhi Lian (SCUTELLARIA BARBABA), Shen Qu(MASSA FERMENTATA MEDICALIS), Chai Hu (BUPLEURUM SCORZONERIFOLIUM), BanXia (PINELLIA TERNATA), Chen Pi (CITRUS RETICULATA), Chuan Lian Zi(MELIA TOOSENDAN), Bai Shao (PAEONIA LACTIFLORA), Ling Zhi (GANODERMALUCIDUM), and Jiang (dry or fresh) (ZINGIBER OFFICINALE).

More specifically, the preferred compositions comprise Red Ginseng(PANAX GINSING), Fu Ling (PORIA COCOS), Bai Zhu (ATRACTYLODESMACROCEPHALA), Huang Qi (ASTRAGALUS MEMBRANACEUS), Huang Qin(SCUTELLARIA BAICALENSIS), Huang Lian (COPTIS CHINENSIS), Gan Cao(GLYCYRRHIZA URALENSIS), Mai Ya (HORDEUM VULGARE), Bai Hua She She Cao(HEDYOTIS DIFFUSA), Ban Bian Lian (LOBELIA CHINESIS LOUR), Ban Zhi Lian(SCUTELLARIA BARBABA), Shen Qu (MASSA FERMENTATA MEDICALIS), and one ormore of the following: Dang Gui (ANGELIC SINENSIS), E Zhu (CURCUMAZEDOARIA), Huang Bai (PHELLODRON CHINENSE), Shan Zha (CRATAEGUSPINATIFIDA), Dan Shen (SALVIA MILTIORRHIZA), Wu Wei Zi (SCHISANDRACHINENSIS), Mai Men Dong (OPHIOPHOGON JAPONICUS), Chai Hu (BUPLEURUMSCORZONERIFOLIUM), Ban Xia (PINELLIA TERNATA), Chen Pi (CITRUSRETICULATA, Chuan Lian Zi (MELIA TOOSENDAN), Bai Shao (PAEONIALACTIFLORA), Ling Zhi (GANODERMA LUCIDUM), and Jiang (dry or fresh)(ZINGIBER OFFICINALE).

The following specific prescriptions are the most preferredcompositions. Prescription 1 is a primary or basic composition andPrescriptions 2 to 6 are adding or reducing compositions. Additionalaspects of these compositions and their use are described in greaterdetail herein.

PRESCRIPTION 1 % amount Name (pinyin) Latin Name (species) (w/w) Red RenShen PANAX GINSING 9.4% Fu Ling PORIA COCOS 5.7% Bai Zhu ATRACTYLODESMACROCEPHALA 5.7% Dang Gui ANGELIC SINENSIS 6.6% Huang Qi ASTRAGALUSMEMBRANACEUS 5.7% E Zhu CURCUMA ZEDOARIA 4.7% Huang Qin SCUTELLARIABAICALENSIS 5.7% Huang Bai PHELLODRON CHINENSE 4.7% Huang Lian COPTISCHINENSIS 5.7% Gan Cao GLYCYRRHIZA URALENSIS 5.7% Shan Zha CRATAEGUSPINATIFIDA 4.7% Mai Ya HORDEUM VULGARE 1.8% Dan Shen SALVIA MILTIORRHIZA4.7% Wu Wei Zi SCHISANDRA CHINENSIS 5.7% Bai Hua She She Cao HEDYOTISDIFFUSA 6.6% Mai Men Dong OPHIOPHOGON JAPONICUS 4.7% Ban Bian LianLOBELIA CHINESIS LOUR 4.7% Ban Zhi Lian SCUTELLARIA BARBABA 5.7% Shen QuMASSA FERMENTATA MEDICALIS 1.8%

PRESCRIPTION 2 % amount Name (pinyin) Latin Name (species) (w/w) Red RenShen PANAX GINSING 9.4 (1-15)% Fu Ling PORIA COCOS 5.7 (1-10)% Bai ZhuATRACTYLODES MACROCEPHALA 5.7 (1-10)% Dang Gui ANGELIC SINENSIS 6.6(1-10)% Huang Qi ASTRAGALUS MEMBRANACEUS 5.7 (1-10)% E Zhu CURCUMAZEDOARIA 4.7 (1-10)% Huang Qin SCUTELLARIA BAICALENSIS 5.7 (1-25)% HuangBai PHELLODRON CHINENSE 4.7 (1-20)% Huang Lian COPTIS CHINENSIS 5.7(1-20)% Gan Cao GLYCYRRHIZA URALENSIS 5.7 (1-15)% Shan Zha CRATAEGUSPINATIFIDA 4.7 (1-10)% Mai Ya HORDEUM VULGARE 1.8 (1-20)% Dan ShenSALVIA MILTIORRHIZA 4.7 (1-15)% Wu Wei Zi SCHISANDRA CHINENSIS 5.7(1-15)% Bai Hua She HEDYOTIS DIFFUSA 6.6 (1-40)% She Cao Mai Men DongOPHIOPHOGON JAPONICUS 4.7 (1-20)% Ban Bian Lian LOBELIA CHINESIS LOUR4.7 (1-25)% Ban Zhi Lian SCUTELLARIA BARBABA 5.7 (1-25)% Shen Qu MASSAFERMENTATA MEDICALIS 1.8 (1-20)%

PRESCRIPTION 3 % amount Name (pinyin) Latin Name (species) (w/w) Red RenShen PANAX GINSING 9.4 (1-30)% Fu Ling PORIA COCOS 5.7 (1-30)% Bai ZhuATRACTYLODES MACROCEPHALA 5.7 (1-30)% Dang Gui ANGELIC SINENSIS 6.6(1-30)% Huang Qi ASTRAGALUS MEMBRANACEUS 5.7 (1-30)% E Zhu CURCUMAZEDOARIA 4.7 (1-30)% Huang Qin SCUTELLARIA BAICALENSIS 5.7 (1-35)% HuangBai PHELLODRON CHINENSE 4.7 (1-30)% Huang Lian COPTIS CHINENSIS 5.7(1-30)% Gan Cao GLYCYRRHIZA URALENSIS 5.7 (1-30)% Shan Zha CRATAEGUSPINATIFIDA 4.7 (1-30)% Mai Ya HORDEUM VULGARE 1.8 (1-30)% Dan ShenSALVIA MILTIORRHIZA 4.7 (1-30)% Wu Wei Zi SCHISANDRA CHINENSIS 5.7(1-30)% Bai Hua She HEDYOTIS DIFFUSA 6.6 (1-40)% She Cao Mai Men DongOPHIOPHOGON JAPONICUS 4.7 (1-30)% Ban Bian Lian LOBELIA CHINESIS LOUR4.7 (1-35)% Ban Zhi Lian SCUTELLARIA BARBABA 5.7 (1-35)% Shen Qu MASSAFERMENTATA MEDICALIS 1.8 (1-30)%

PRESCRIPTION 4 % amount Name (pinyin) Latin Name (species) (w/w) Red RenShen PANAX GINSING 9.4 (1-30)% Fu Ling PORIA COCOS 5.7 (1-30)% Bai ZhuATRACTYLODES MACROCEPHALA 5.7 (1-30)% Dang Gui ANGELIC SINENSIS 6.6(1-30)% Huang Qi ASTRAGALUS MEMBRANACEUS 5.7 (1-30)% Huang QinSCUTELLARIA BAICALENSIS 5.7 (1-30)% Huang Lian COPTIS CHINENSIS 5.7(1-30)% Huang Bai PHELLODRON CHINENSE 4.7 (1-30)% Gan Cao GLYCYRRHIZAURALENSIS 5.7 (1-30)% Mai Ya HORDEUM VULGARE 1.8 (1-30)% Bai Hua SheHEDYOTIS DIFFUSA 6.6 (1-40)% She Cao Ban Bian Lian LOBELIA CHINESIS LOUR4.7 (1-30)% Ban Zhi Lian SCUTELLARIA BARBABA 5.7 (1-30)% Shen Qu MASSAFERMENTATA MEDICALIS 1.8 (1-30)% Chai Hu BUPLEURUM SCORZONERIFOLIUM   5(1-30)% Ban Xia PINELLIA TERNATA   5 (1-30)% Chen Pi CITRUS RETICULATA  5 (1-30)% Chuan Lian Zi MELIA TOOSENDAN   5 (1-30)% Bai Shao PAEONIALACTIFLORA   4 (1-30)% Jiang(GAN ZINGIBER OFFICINALE(dry or fresh)   2(1-30)% or SHENG)

PRESCRIPTION 5 % amount Name (pinyin) Latin Name (species) (w/w) Red RenShen PANAX GINSING 9.4 (1-30)% Fu Ling PORIA COCOS 5.7 (1-30)% Bai ZhuATRACTYLODES MACROCEPHALA 5.7 (1 -30)% Dang Gui ANGELIC SINENSIS 6.6(1-30)% Huang Qi ASTRAGALUS MEMBRANACEUS 5.7 (1-30)% Huang QinSCUTELLARIA BAICALENSIS 5.7 (1-30)% Huang Lian COPTIS CHINENSIS 5.7(1-30)% Huang Bai PHELLODRON CHINENSE 4.7 (1-30)% Gan Cao GLYCYRRHIZAURALENSIS 5.7 (1-30)% Mai Ya HORDEUM VULGARE 1.8 (1-30)% Ban Bian LianLOBELIA CHINESIS LOUR 4.7 (1-30)% Bai Hua She HEDYOTIS DIFFUSA 6.6(1-40)% She Cao Ban Zhi Lian SCUTELLARIA BARBABA 5.7 (1-30)% Shen QuMASSA FERMENTATA MEDICALIS 1.8 (1-30)% Chai Hu BUPLEURUMSCORZONERIFOLIUM   5 (1-20)% Ban Xia PINELLIA TERNATA   5 (1-30)% ChenPi CITRUS RETICULATA   5 (1-30)% Chuan Lian Zi MELIA TOOSENDAN   5(1-30)% Bai Shao PAEONIA LACTIFLORA   4 (1-30)%

In prescription 5, 2 (1-30) % of JIANG (GAN or SHENG) (ZINGIBEROFFICINALE) (dry or fresh) can be added, or 4.7 (1-30) % of Huang Bai(PHELLODRON CHINENSE) can be cancelled.

PRESCRIPTION 6 % amount Name (pinyin) Latin Name (species) (w/w) Red RenShen PANAX GINSING 9.4 (1-30)% Fu Ling PORIA COCOS 5.7 (1-30)% Bai ZhuATRACTYLODES MACROCEPHALA 5.7 (1-30)% Dang Gui ANGELIC SINENSIS 6.6(1-30)% Huang Qi ASTRAGALUS MEMBRANACEUS 5.7 (1-30)% Huang QinSCUTELLARIA BAICALENSIS 5.7 (1-30)% Huang Lian COPTIS CHINENSIS 5.7(1-30)% Huang Bai PHELLODRON CHINENSE 4.7 (1-30)% Gan Cao GLYCYRRHIZAURALENSIS 5.7 (1-30)% Mai Ya HORDEUM VULGARE 1.8 (1-30)% Ban Bian LianLOBELIA CHINESIS LOUR 4.7 (1-30)% Bai Hua She HEDYOTIS DIFFUSA 6.6(1-40)% She Cao Ban Zhi Lian SCUTELLARIA BARBABA 5.7 (1-30)% Shen QuMASSA FERMENTATA MEDICALIS 1.8 (1-30)% Chai Hu BUPLEURUMSCORZONERIFOLIUM   5 (1-30)% Ban Xia PINELLIA TERNATA   5 (1-30)% ChenPi CITRUS RETICULATA   5 (1-30)% Chuan Lian Zi MELIA TOOSENDAN   5(1-30)% Bai Shao PAEONIA LACTIFLORA   4 (1-30)% Ling Zhi GANODERMALUCIDUM   6 (1-30%)

In prescription 6, 2 (1-30)% of Jiang (GAN or SHENG) (ZINGIBEROFFICINALE) (dry or fresh) can be added, or 4.7 (1-30)% of Huang Bai(PHELLODRON CHINENSE) can be cancelled.

In each above mentioned prescriptions, the numbers shown in parenthesisrepresent that the percentage amount can vary within the range. Thenumber shown immediately before the parenthesis is the preferredconcentration. For example, in Prescription 6, Ling Zhi is preferablyused in a concentration of 6%, however it may be used in a concentrationof 1-30%. Furthermore, it will be appreciated that all percentages areapproximate.

The new anti-neoplastic compositions of the present invention aredesignated herein as Anti-Cancer Number One (hereinafter referred to assimply ACNO). These compositions provide new anti-cancer drugs andtreatment regimes based upon traditional Chinese medicines andpractices. The prescriptions are based upon Si Junzi Tang (Decoction ofFour Noble Drugs) and Huanglian Jiedu Tang (Antidotal Decoction ofcoptis), and are formulated by adding therein drugs or agents forreplenishing Qi and blood, and including other agents for detoxifyingand providing an anti-tumor function. The function of Si Junzi Tang isto replenish Qi and strengthen the spleen. Among the four ingredients inthe prescription, Ginseng is sweet in flavor and warm in nature, andpossesses the effect of invigorating primordial Qi and acts as aprincipal drug to strengthen the spleen and nourish the stomach. Bai Zhuhas a bitter flavor and warm nature and is effective for strengtheningthe spleen and eliminating dampness and is considered as an assistantdrug. Fu Ling, being sweet and insipid in flavor, serves as an adjuvantdrug in achieving the effect of strengthening the spleen. Gan Cao, beingsweet in flavor and warm in nature, is used as a guiding drug forregulating the meddle-warmer. In the Huanglian Jiedu Tang, ingredientHuang Lian is used as principal drug, which plays a significant role ofpurging pathogenic fire in the heart and middle-energizer. Huang Qinacts as an assistant drug with the effect of clearing away heat in thelung and purging fire in the upper-energizer. Huang Bai is used as bothadjuvant and guiding drugs, the former provides the effect of purgingpathogenic fire in lower-energizer and the latter have the effect ofremoving pathogenic fire in the tri-energizer by inducing diuresis.

In the prescriptions of the present invention, Ginseng, Huang Qi, BaiZhu, Gan Cao, which are sweet in flavor and warm in nature, are able tostrengthen the spleen and invigorate the Qi. Dang Gui, which is sweetand pungent in flavor and warm in property, can play the role oftonifying the blood and nourishing the liver. E Zhu relieves thestagnation of Qi, alleviates pain and invigorates blood circulation. DanShen can invigorate blood circulation, remove blood stasis, remove heatfrom blood, treat carbuncles, and tranquilizes the disturbed mind bynourishing the blood. Wu Wei Zi nourishes the kidney and tranquilizesthe mind. Mai Man Dong nourishes yin, promotes the production of bodyliquid and clears away heat-fire to relieve vexation, which combineswith Ren Shen for treating the injury of Qi and Yin by heat, palpitationand pulse insufficiency of the patient after chemotherapy. Bai Hua SheShe Cao, Bai Zhi Lian, and Ban Bian Lian assist Huang Lian Jie Du Tangwith clearing heat and detoxifying to fight against tumors. Shan Zha,Mai ya, and Shen Qu strengthen the spleen and improve digestion in orderto prevent the drugs for replenishing Qi and blood (Yi Qi Bu Xue Yao)from growing and loathing Qi to block the spleen and the stomach'sfunction of transport and digestion. The action of the whole formula istonifying but not stagnant, and is purgation but not asthenia. So, theformula increases an organism's immunity function and inhibits/kills thetumor at the same time. Therefore, the prescriptions of the presentinvention are developed according to a theory of strengthening a body'sresistance to eliminate pathogenic factors of traditional Chinesemedicine. Furthermore, the various prescriptions are based upon a theoryof increasing the function of the immune system, improving anti-stressand anti-tumor characteristics and further improving micro-circulationto reverse and destroy tumor cells of Western medicine.

Extensive clinical testing of ACNO has revealed that the use of ACNO fortreating patients with cancer leads to excellent clinical efficacyresults. Effective treatment rates of 69.7% have been obtained. Whenadministered in combination with radiotherapy or chemotherapy, effectivetreatment rates of 84.3% have been obtained.

Distinguished from Western medicine, the main principles of cancertreatment in anti-cancer number one (ACNO) are: searching for theprimary cause of disease in treatment, and treating the physical andmental aspects as a whole instead of paying attention to the localtarget lesion only. This therapeutic method was easy, effective, andsafe without any adverse effect, which renders it suitable for theelderly and asthenics, who are unable or who have failed to receive anoperation, chemotherapy and/or radiotherapy. It has been demonstrated byclinical practice that ACNO inhibits/kills cancer cells (eliminatingpathogenic factors); enhances the immune function of the organism,increases NK cells' activity; possesses the function of anti-stress andimproves micro-circulation and suppresses the genesis and metastasis oftumor; increases sensitivity to other therapies and diminishes toxic andadverse action of other therapies and drugs. So, ACNO enhances thebody's anti-tumor capacity, improves the patient's quality of life andreduces or prevents the genesis, relapse and metastasis of tumors. Forfurther proving the therapeutic efficacy of ACNO, animal trials wereconducted at the Tel-Aviv University of Israel to test the effects ofACNO on natural killer cell activity and metastasis of tumors.

Research Efforts in Animals

Experiments and Materials

1. Fischer-344 male and female rats (Harlan Laboratories of Jerusalem,Israel) were housed four in a cage with free access to food and water adlibitum in a 12:12 hours lighting regiment. Animals were acclimatized tothe surrounding for at least 3 weeks before any experiment, and wereweighed three times. All experiments were conducted during the firsthalf of the light phase. In each experiment, all animals were of thesame age.

2. ACNO was prepared in China, and contained Red Ginseng, AtractylodesMacrocephala, Poria Cocos, etc. The ACNO composition was as describedherein.

3. The experimental animals were divided into a test group and a controlgroup. The animals in the test group were fed with 0.1, 0.5, 2 g/kg bodyweight ACNO mixed and standard powdered rodent food to which water wasadded (test food), every day. The animals in the control group receivedthe same wet food mixture without ACNO (control food) in the sameamount. All animals were fed at regular times every day. To adjustanimals to the feeding protocol, all rats received the wet mixturewithout ACNO for 3 days before each experiment. Thereafter, the animalswere fed test food and control food, respectively. Rats from all groupsconsumed more than 95% of the food each day. Approximately 70% of it wasconsumed during the dark phase. Body weight of each animal was monitoredtwice a week during the experiment.

4. MADB106 tumor cell—MADB106 cell was obtained from a pulmonarymetastasis of a mammary adenocarcinoma (MADB100) by a specialincubation.

5. Induction and counting of tumor metastasis—Rats were lightlyanesthetized with halothane, and then 10⁵ MADB106 tumor cells wereinjected into their tail vein. At the same time, number 3 and 4 of theanimals in every group were injected with 0.8 ml β-receptor agonistMetaproterenol MP. Rats were anesthetized with halothane after they werefed with ACNO for 3 weeks counted from the day of tumor inoculation, andtheir lungs were removed and placed in Bouin solution (72% saturatedpicric acid solution, 23% formaldehyde [37% solution] and 5% glacialacetic acid) for 24 h. Thereafter, the lungs were washed with ethanol,and then the cell number of pulmonary metastasis were counted by twoexperimenters unaware of the group origin (in a blind technique),independently. The obtained data were analyzed statistically.

6. After the animals had been fed with the test food for 2 weeks, 1 mlof blood was drawn by cardiac puncture to detect the number of NK cellsper ml and the activity thereof.

Statistical Analysis

ANOVA method was applied for detecting the number of NK cells per ml andthe activity thereof, while a T test and the ANOVA test were used forthe count of the cell number of pulmonary tumors.

Experimental Method

1. The Effect of ACNO on Number and Activity of NK Cells

78% healthy female Fisher rats that were 10-12 weeks old and of 250-350g body weight, were randomly divided into 5 groups, wherein 3 groupswere administrated ACNO with high, middle and low dosage (0.1, 0.5, 2.0g/kg body weight/day). There were 14, 15, 14, 15 and 20 rats in a low, amiddle, and a high dosage groups, a Panax ginsing group (0.5 g PanaxGinsing/kg body weight/day) and a control group (fed with the controlfood in same amount only), respectively. Two weeks after administration,rats were lightly anesthetized with halothane, blood samples were drawnby cardiac puncture and placed into a tube with heparin, and centrifugedto collect monocytes. The monocytes were washed with PBS twice, and theconcentration of the cells were adjusted to 0.25×10⁷. Thereafter, thenumber of NK cells were counted, and the activity of NK cells wasdetected by the method using YAC-1 or MADB106 target cells by releasing⁵¹Cr or ¹²⁵IDUR.

2. The Effect of ACNO on Susceptibility to Tumor Cells Metastasis

89 healthy female Fischer rats that were 7-8 weeks old and of 120-170 gbody weight (48 females and 61 males), were randomly divided into 2groups, an experiment group and a control group. There were 40 rats (20females and 20 males) and 49 rats (20 females and 29 males) in theexperiment group and the control group, respectively. The animals in theexperiment group were fed with 2 g/kg body weight/day ACNO andwater-added mix food while those in the control group were fed withwater-added mix food in same amount. After 3 weeks of feeding, rats werelightly anesthetized with halothane, and then 0.5 ml of 4×105 tumorcells were injected into their tail vein. At the same time, 0.8 ml ,β-receptor agonist (MP) were injected. Three weeks after inoculatingtumor cells, rats were anesthetized with halothane, and then their lungswere removed and fixed in Bouin solution for 24 h. Thereafter, the lungswere washed with ethanol, and then the cell number of pulmonarymetastasis were counted by two experimenters unaware of the group origin(in a blind technique), independently. The obtained data were analyzedstatistically.

Results

1. The Effect of ACNO on NK Cells

Rats from all groups consumed 95% of their food each day, and during theexperimental period, gained an average of 23.4 g/week in body weightwith no significant difference among various groups.

The results showed that ACNO caused a significant dose-dependentincrease in activity of NK cells per ml blood. FIG. 1 illustrates thespecific percentages of different E:T rates in various groups. Comparedto the animals in the control group, those in the high dose group showeda significantly higher activity of NK cells (P<0.0001), and the otheradministration groups also showed increased activity of NK cells to adifferent degree without significant difference. This result suggestedthat the effect of a high dose was superior to that of a low dose. Onthe other hand, ACNO also caused an increased number of NK cells/mlblood, wherein the number value of NK cells/ml blood in the controlgroup is 344.4±34.9 (mean±SD), that in the high dose group is 530±79.1(mean±SD), that in the medium dose group is 407.7±63.6 (mean±SD), thatin the low dose group is 382.2±53.2 (mean±SD), and that in the PanaxGinsing group is 373±65.1 (mean±SD). This result demonstrated that ACNOincreased significantly the activity and number of NK cells.

Specifically, FIG. 1 illustrates the effects of increasing doses of ACNO(low, medium, high: 0.1, 0.5, or 2 g/kg/day) on NK activity (% specifickilling) in increasing effector to target (E/T) ratios. Data arepresented as means±S.E.M. ACNO caused a significant dose dependentincrease in NK activity without significantly affecting the number of NKcells (not shown). FIG. 2 shows the effects of ACNO (2 g/kg/day) and ofthe β-adrenergic agonist, metaproterenol (0.8 mg/kg), on the number ofMADB106 metastases. Data are presented as means±S.E.M. Metaproterenolinjection significantly increased the number of metastases, and ACNOsignificantly reduced this effect of metaproterenol (*) without alteringbaseline levels of metastasis (in saline-injected animals).

2. The Effect of ACNO on Tumor Cells Metastasis

During the experimental period, rats from the two groups consumed 95% oftheir food, and gained an average of 20.5 g/week (males) or log/week(females) in body weight, with no significant difference as compared tothe third group maintained on ad libitum dry food schedule.

With respect to cell number of metastasis, the difference between thosecounted by the two experimenters was lower than 0.9, and the averagethereof was used. There is no significant difference among the threegroups (dry food, wet food only, and ACNO group) without theadministration of β-receptor agonist. However, compared to the 2 controlgroups without the administration of β-receptor agonist, the 2 controlgroups with the administration of β-receptor agonist, caused a 4 to 5.5fold increase in the cell number of metastases (NS70+14, MP255+32),while ACNO-treated groups only caused a 2.3 fold increase(ACNO+MP154+18, control group+MP255+32), P<0.0006. This experimentalresult showed that the state of stress and anxiety significantlypromoted the tumor metastases, however, ACNO remarkably inhibited thetumor metastases under the state of stress and anxiety.

The Beneficial Effects of the Invention

It is considered in traditional Chinese medicine that tumorigenesisusually results from external evil invasion, which could cause afunctional disturbance in Yin and Yang, Qi and blood, channels andcollaterals as well as the viscera and bowels. Therefore, the principleof cancer treatment in traditional Chinese medicine emphasizesregulating visceral function, consolidating the constitution andeliminating pathogenic factors. In recent years, Western medicineresearchers have suggested that the main reason for tumorigenesis isthat the immune function of patients was inhibited. So, increasing theimmune function of the body and inhibiting the cancer cells are veryimportant methods in the treatment of cancer.

Natural killer cells are provided by the immune system of the body. NKcells constitute a first line of defense against infectious disease andplay a very important role in preventing the tumorigenesis and tumormetastases. The results of animal trials performed at the Immunology Labof Tel-Aviv University of Israel demonstrated convincingly that NK cellsplayed very important roles in controlling various aspects of tumordevelopment, including the metastatic process, the tumorigenic effectsof cancinogenes and the primary seeding of implanted solid tumors. ACNOcan increase the number and activity of NK cells and inhibit the growthof tumors and prevent metastasis.

It has been suggested that Scutellaria Baicalensis, Coptis Chinesis, andPhellodron Chinensis, which are contained in the ACNO, are cytotoxicanti-cancer drugs; and Red Ginseng belongs to a class ofchemoprophylactic agents of cancer. The resistance of anti-cancer drugsrepresents a major cause of failure in cancer chemotherapy, and toresolve this problem, extensive research was conducted and showed RedGinseng is a new reversal agent with non-toxic effects.

Also, a series of tests were carried out to study the anti-cancereffects of ginsenoside Rg3. The pharmacological studies showed: (1)anti-tumor metastasis; (2) anti-cancer effects in that the inhibitionrate of Rg3 against B16 melanoma, LEWIS lung cancer, and S180 sarcoma bysubcutaneous transplantation were 50-60%; (3) Immunoenhancement effectssince Rg3 administrated orally can remarkably enhance the NK and IL-2activity of lung cancer implanted mice and normal mice; and (4) Rg3 canenhance the anti-cancer effect and reduce the side effects ofchemotherapy. The studies on the mechanism of Rg3 showed that Rg3 caninhibit the proliferation, infiltration and metastasis of tumor cells,and enhance the immunological function of mice bearing tumors.

Astragalus membranaceus, salvia miltiorrhiza etc. possess the functionof increasing the immunological function of organisms. The effectivecomponent of Curcuma zedoaria is cellular toxic, which inhibits theproliferation of tumor cells by inhibiting the protein syntheticprocesses of DNA and RNA, which might induce the termination of tumorcells' growth by way of blocking the cells' respiration in certainstages or destroying the cellular membrane to cause autolysis of thetumor cells. Astragalus Membranaceus combined with chemotherapy,radiotherapy and biological therapy may enhance the therapeutic effectand reduce the side effect thereof. The polysaccharide components ofRadix Ginseng have reticuloendothelial system function-enhanced effectand contain trace amounts of Germanium (Ge), which has been known as aneffective cancer-preventing element. The study of Ge in cancerprevention has vast prospects. The animal trials showed that ACNO canincrease cytotoxic activity and the number of NK cells and suppresstumor metastasis. This result is consistent with that obtained fromclinical trials and therefore is worthy of further research. ACNO andrelated treatment regimes using this composition, shall open a newavenue for preventing and treating cancer.

The anti-neoplastic compositions can increase immunity, inhibit tumorcells and reverse cells to a normal state; sedate the patient, andimprove blood circulation in order to suppress the growth and metastasisof tumor; increase the sensitivity to radiotherapy and chemotherapy andreduce the toxic and adverse effects of radiotherapy and chemotherapy;improve sleeping, increase appetite, alleviate pain, and protect thefunction of the liver, kidney and ovaries; and increase the number ofleukocyte and hemoglobin otherwise reduced by radiotherapy andchemotherapy. The compositions can also enhance the anti-tumor abilityof the organism, prevent the relapse of tumors, improve the tumorpatient's quality of life and prevent tumorigenesis.

The Chinese herbal medicines used in each prescription are availablecommercially in China. The various medicinal herbs were weighedaccording to the herbs employed and their percentage showed in theprescription, and then ground to powder, and encapsulated into capsules,0.5 g per capsule.

The foregoing description is, at present, considered to be the preferredembodiments of the present invention. However, it is contemplated thatvarious changes and modifications apparent to those skilled in the art,may be made without departing from the present invention. Therefore, theforegoing description is intended to cover all such changes andmodifications encompassed within the spirit and scope of the presentinvention, including all equivalent aspects.

1. A composition for treatment of tumors, comprising effective amounts:Red Ren Shen (PANAX GINSING), Fu Ling (PORIA COCOS), Bai Zhu(ATRACTYLODES MACROCEPHALA), Huang Qi (ASTRAGALUS MEMBRANACEUS), HuangQin (SCUTELLARIA BAICALENSIS), Huang Lian (COPTIS CHINENSIS), Gan Cao(GLYCYRRHIZA URALENSIS), Mai Ya (HORDEUM VULGARE), Bai Hua She She Cao(HEDYOTIS DIFFUSA), Ban Bian Lian (LOBELIA CHINESIS LOUR), Ban Zhi Lian(SCUTELLARIA BARBABA), Shen Qu (MASSA FERMENTATA MEDICALIS), and atleast one agent selected from the group consisting of Dang Gui (ANGELICSINENSIS), E Zhu (CURCUMA ZEDOARIA), Huang Bai (PHELLODRON CHINENSE),Shan Zha (CRATAEGUS PINATIFIDA), Dan Shen (SALVIA MILTIORRHIZA), Wu WeiZi (SCHISANDRA CHINENSIS), Mai Men Dong (OPHIOPHOGON JAPONICUS), Chai Hu(BUPLEURUM SCORZONERIFOLIUM), Ban Xia (PINELLIA TERNATA), Chen Pi(CITRUS RETICULATA), Chuan Lian Zi (MELIA TOOSENDAN), Bai Shao (PAEONIALACTIFLORA), Ling Zhi (GANODERMA LUCIDUM), and Jiang (dry or freshZINGIBER OFFICINALE).
 2. The composition for treatment of tumorsaccording to claim 1, comprising: about 9.4% Red Ren Shen (PANAXGINSENG); about 5.7% Fu Ling (PORIA COCOS); about 5.7% Bai Zhu(ATRACTYLODES MACROCEPHALA); about 6.6% Dang Gui (ANGELIC SINENSIS)about 5.7% Huang Qi (ASTRAGALUS MEMBRANACEUS); about 4.7% E Zhu (CURCUMAZEDOARIA); about 5.7% Huang Qin (SCUTELLARIA BAICALENSIS); about 4.7%Huang Bai (PHELLODRON CHINENSE); about 5.7% Huang Lian (COPTISCHINENSIS); about 5.7% Gan Cao (GLYCYRRHIZA URALENSIS); about 4.7% ShanZha (CRATAEGUS PINATIFIDA); about 1.8% Mai Ya (HORDEUM VULGARE); about4.7% Dan Shen (SALVIA MILTIORRHIZA); about 5.7% Wu Wei Zi (SCHISANDRACHINENSIS); about 6.6% Bai Hua She (HEDYOTIS DIFFUSA); She Cao about4.7% Mai Men Dong (OPHIOPHOGON JAPONICUS); about 4.7% Ban Bian Lian(LOBELIA CHINESIS LOUR); about 5.7% Ban Zhi Lian (SCUTELLARIA BARBABA);about 1.8% Shen Qu (MASSA FERMENTATA MEDICALIS).


3. The composition for treatment of tumors according to claim 1,comprising: about 1-15% Red Ren Shen (PANAX GINSENG); about 1-10% FuLing (PORIA COCOS); about 1-10% Bai Zhu (ATRACTYLODES MACROCEPHALA);about 1-10% Dang Gui (ANGELIC SINENSIS); about 1-10% Huang Qi(ASTRAGALUS MEMBRANACEUS); about 1-10% E Zhu (CURCUMA ZEDOARIA); about1-25% Huang Qin (SCUTELLARIA BAICALENSIS); about 1-20% Huang Bai(PHELLODRON CHINENSE); about 1-20% Huang Lian (COPTIS CHINENSIS); about1-15% Gan Cao (GLYCYRRHIZA URALENSIS); about 1-10% Shan Zha (CRATAEGUSPINATIFIDA); about 1-20% Mai Ya (HORDEUM VULGARE); about 1-15% Dan Shen(SALVIA MILTIORRHIZA); about 1-15% Wu Wei Zi (SCHISANDRA CHINENSIS);about 1-40% Bai Hua She (HEDYOTIS DIFFUSA); She Cao about 1-20% Mai MenDong (OPHIOPHOGON JAPONICUS); about 1-25% Ban Bian Lian (LOBELIACHINESIS LOUR); about 1-25% Ban Zhi Lian (SCUTELLARIA BARBABA); about1-20% Shen Qu (MASSA FERMENTATA MEDICALIS).


4. The composition for treatment of tumors according to claim 3,comprising: about 9.4% Red Ren Shen (PANAX GINSENG); about 5.7% Fu Ling(PORIA COCOS); about 5.7% Bai Zhu (ATRACTYLODES MACROCEPHALA); about6.6% Dang Gui (ANGELIC SINENSIS); about 5.7% Huang Qi (ASTRAGALUSMEMBRANACEUS); about 4.7% E Zhu (CURCUMA ZEDOARIA); about 5.7% Huang Qin(SCUTELLARIA BAICALENSIS); about 4.7% Huang Bai (PHELLODRON CHINENSE);about 5.7% Huang Lian (COPTIS CHINENSIS); about 5.7% Gan Cao(GLYCYRRHIZA URALENSIS); about 4.7% Shan Zha (CRATAEGUS PINATIFIDA);about 1.8% Mai Ya (HORDEUM VULGARE); about 4.7% Dan Shen (SALVIAMILTIORRHIZA); about 5.7% Wu Wei Zi (SCHISANDRA CHINENSIS); about 6.6%Bai Hua She (HEDYOTIS DIFFUSA); She Cao about 4.7% Mai Men Dong(OPHIOPHOGON JAPONICUS); about 4.7% Ban Bian Lian (LOBELIA CHINESISLOUR); about 5.7% Ban Zhi Lian (SCUTELLARIA BARBABA); about 1.8% Shen Qu(MASSA FERMENTATA MEDICALIS).


5. The composition for treatment of tumors according to claim 1,comprising: about 1-30% Red Ren Shen (PANAX GINSENG); about 1-30% FuLing (PORIA COCOS); about 1-30% Bai Zhu (ATRACTYLODES MACROCEPHALA);about 1-30% Dang Gui (ANGELIC SINENSIS); about 1-30% Huang Qi(ASTRAGALUS MEMBRANACEUS); about 1-30% E Zhu (CURCUMA ZEDOARIA); about1-35% Huang Qin (SCUTELLARIA BAICALENSIS); about 1-30% Huang Bai(PHELLODRON CHINENSE); about 1-30% Huang Lian (COPTIS CHINENSIS); about1-30% Gan Cao (GLYCYRRHIZA URALENSIS); about 1-30% Shan Zha (CRATAEGUSPINATIFIDA); about 1-30% Mai Ya (HORDEUM VULGARE); about 1-30% Dan Shen(SALVIA MILTIORRHIZA); about 1-30% Wu Wei Zi (SCHISANDRA CHINENSIS);about 1-40% Bai Hua She (HEDYOTIS DIFFUSA); She Cao about 1-30% Mai MenDong (OPHIOPHOGON JAPONICUS); about 1-35% Ban Bian Lian (LOBELIACHINESIS LOUR); about 1-35% Ban Zhi Lian (SCUTELLARIA BARBABA); about1-30% Shen Qu (MASSA FERMENTATA MEDICALIS).


6. The composition for treatment of tumors according to claim 5,comprising: about 9.4% Red Ren Shen (PANAX GINSENG); about 5.7% Fu Ling(PORIA COCOS); about 5.7% Bai Zhu (ATRACTYLODES MACROCEPHALA); about6.6% Dang Gui (ANGELIC SINENSIS); about 5.7% Huang Qi (ASTRAGALUSMEMBRANACEUS); about 4.7% E Zhu (CURCUMA ZEDOARIA); about 5.7% Huang Qin(SCUTELLARIA BAICALENSIS); about 4.7% Huang Bai (PHELLODRON CHINENSE);about 5.7% Huang Lian (COPTIS CHINENSIS); about 5.7% Gan Cao(GLYCYRRHIZA URALENSIS); about 4.7% Shan Zha (CRATAEGUS PINATIFIDA);about 1.8% Mai Ya (HORDEUM VULGARE); about 4.7% Dan Shen (SALVIAMILTIORRHIZA); about 5.7% Wu Wei Zi (SCHISANDRA CHINENSIS); about 6.6%Bai Hua She (HEDYOTIS DIFFUSA); She Cao about 4.7% Mai Men Dong(OPHIOPHOGON JAPONICUS); about 4.7% Ban Bian Lian (LOBELIA CHINESISLOUR); about 5.7% Ban Zhi Lian (SCUTELLARIA BARBABA); about 1.8% Shen Qu(MASSA FERMENTATA MEDICALIS).


7. The composition for treatment of tumors according to claim 1,comprising: about 1-30% Red Ren Shen (PANAX GINSENG); about 1-30% FuLing (PORIA COCOS); about 1-30% Bai Zhu (ATRACTYLODES MACROCEPHALA);about 1-30% Dang Gui (ANGELIC SINENSIS); about 1-30% Huang Qi(ASTRAGALUS MEMBRANACEUS); about 1-30% Huang Qin (SCUTELLARIABAICALENSIS); about 1-30% Huang Lian (COPTIS CHINENSIS); about 1-30%Huang Bai (PHELLODRON CHINENSE); about 1-30% Gan Cao (GLYCYRRHIZAURALENSIS); about 1-30% Mai Ya (HORDEUM VULGARE); about 1-40% Bai HuaShe (HEDYOTIS DIFFUSA); She Cao about 1-30% Ban Bian Lian (LOBELIACHINESIS LOUR); about 1-30% Ban Zhi Lian (SCUTELLARIA BARBABA); about1-30% Shen Qu (MASSA FERMENTATA MEDICALIS); about 1-30% Chai Hu(BUPLEURUM SCORZONERIFOLIUM); about 1-30% Ban Xia (PINELLIA TERNATA);about 1-30% Chen Pi (CITRUS RETICULATA); about 1-30% Chuan Lian Zi(MELIA TOOSENDAN); about 1-30% Bai Shao (PAEONIA LACTIFLORA); and about1-30% Jiang (GAN (ZINGIBER OFFICINALE) (dry or fresh). or SHENG)


8. The composition for treatment of tumors according to claim 7,comprising: about 9.4% Red Ren Shen (PANAX GINSENG); about 5.7% Fu Ling(PORIA COCOS); about 5.7% Bai Zhu (ATRACTYLODES MACROCEPHALA); about6.6% Dang Gui (ANGELIC SINENSIS); about 5.7% Huang Qi (ASTRAGALUSMEMBRANACEUS); about 5.7% Huang Qin (SCUTELLARIA BAICALENSIS); about5.7% Huang Lian (COPTIS CHINENSIS); about 4.7% Huang Bai (PHELLODRONCHINENSE); about 5.7% Gan Cao (GLYCYRRHIZA URALENSIS); about 1.8% Mai Ya(HORDEUM VULGARE); about 6.6% Bai Hua She (HEDYOTIS DIFFUSA); She Caoabout 4.7% Ban Bian Lian (LOBELIA CHINESIS LOUR); about 5.7% Ban ZhiLian (SCUTELLARIA BARBABA); about 1.8% Shen Qu (MASSA FERMENTATAMEDICALIS); about 5.0% Chai Hu (BUPLEURUM SCORZONERIFOLIUM) about 5.0%Ban Xia (PINELLIA TERNATA); about 5.0% Chen Pi (CITRUS RETICULATA);about 5.0% Chuan Lian Zi (MELIA TOOSENDAN); about 4.0% Bai Shao (PAEONIALACTIFLORA); and about 2.0% Jiang (GAN (ZINGIBER OFFICINALE) (dry orfresh). or SHENG)


9. The composition for treatment of tumors according to claim 1,comprising: about 1-30% Red Ren Shen (PANAX GINSENG); about 1-30% FuLing (PORIA COCOS); about 1-30% Bai Zhu (ATRACTYLODES MACROCEPHALA);about 1-30% Dang Gui (ANGELIC SINENSIS); about 1-30% Huang Qi(ASTRAGALUS MEMBRANACEUS); about 1-30% Huang Qin (SCUTELLARIABAICALENSIS); about 1-30% Huang Lian (COPTIS CHINENSIS); about 1-30% GanCao (GLYCYRRHIZA URALENSIS); about 1-30% Mai Ya (HORDEUM VULGARE); about1-40% Bai Hua She (HEDYOTIS DIFFUSA); She Cao about 1-30% Ban Bian Lian(LOBELIA CHINESIS LOUR); about 1-30% Ban Zhi Lian (SCUTELLARIA BARBABA);about 1-30% Shen Qu (MASSA FERMENTATA MEDICALIS); about 1-30% Chai Hu(BUPLEURUM SCORZONERIFOLIUM); about 1-30% Ban Xia (PINELLIA TERNATA);about 1-30% Chen Pi (CITRUS RETICULATA); about 1-30% Chuan Lian Zi(MELIA TOOSENDAN); about 1-30% Bai Shao (PAEONIA LACTIFLORA).


10. The composition of claim 9 further comprising: about 1-30% Huang Bai(PHELLODRON CHINENSE).


11. The composition of claim 9 further comprising: about 1-30% Jiang(dry or fresh) (ZINGIBER OFFICINALE).


12. The composition for treatment of tumors according to claim 9,comprising: about 9.4% Red Ren Shen (PANAX GINSENG); about 5.7% Fu Ling(PORIA COCOS); about 5.7% Bai Zhu (ATRACTYLODES MACROCEPHALA); about6.6% Dang Gui (ANGELIC SINENSIS); about 5.7% Huang Qi (ASTRAGALUSMEMBRANACEUS); about 5.7% Huang Qin (SCUTELLARIA BAICALENSIS); about5.7% Huang Lian (COPTIS CHINENSIS); about 5.7% Gan Cao (GLYCYRRHIZAURALENSIS); about 1.8% Mai Ya (HORDEUM VULGARE); about 6.6% Bai Hua She(HEDYOTIS DIFFUSA); She Cao about 4.7% Ban Bian Lian (LOBELIA CHINESISLOUR); about 5.7% Ban Zhi Lian (SCUTELLARIA BARBABA); about 1.8% Shen Qu(MASSA FERMENTATA MEDICALIS); about 5.0% Chai Hu (BUPLEURUMSCORZONERIFOLIUM) about 5.0% Ban Xia (PINELLIA TERNATA); about 5.0% ChenPi (CITRUS RETICULATA); about 5.0% Chuan Lian Zi (MELIA TOOSENDAN);about 4.0% Bai Shao (PAEONIA LACTIFLORA).


13. The composition of claim 12 further comprising: about 4.7% Huang Bai(PHELLODRON CHINENSE).


14. The composition of claim 12 further comprising: about 2.0% Jiang(dryor fresh) (ZINGIBER OFFICINALE).


15. The composition for treatment of tumors according to claim 1,comprising: about 1-30% Red Ren Shen (PANAX GINSENG); about 1-30% FuLing (PORIA COCOS). about 1-30% Bai Zhu (ATRACTYLODES MACROCEPHALA);about 1-30% Dang Gui (ANGELIC SINENSIS); about 1-30% Huang Qi(ASTRAGALUS MEMBRANACEUS); about 1-30% Huang Qin (SCUTELLARIABAICALENSIS); about 1-30% Huang Lian (COPTIS CHINENSIS); about 1-30% GanCao (GLYCYRRHIZA URALENSIS); about 1-30% Mai Ya (HORDEUM VULGARE); about1-40% Bai Hua She (HEDYOTIS DIFFUSA); She Cao about 1-30% Ban Bian Lian(LOBELIA CHINESIS LOUR); about 1-30% Ban Zhi Lian (SCUTELLARIA BARBABA);about 1-30% Shen Qu (MASSA FERMENTATA MEDICALIS); about 1-30% Chai Hu(BUPLEURUM SCORZONERIFOLIUM) about 1-30% Ban Xia (PINELLIA TERNATA);about 1-30% Chen Pi (CITRUS RETICULATA); about 1-30% Chuan Lian Zi(MELIA TOOSENDAN); about 1-30% Bai Shao (PAEONIA LACTIFLORA); and about1-30% Ling Zhi (GANODERMA LUCIDUM).


16. The composition of claim 15 further comprising: about 1-30% HuangBai (PHELLODRON CHINENSE).


17. The composition of claim 15 further comprising: about 1-30% Jiang(GAN or SHENG) (ZINGIBER OFFICINALE) (dry or fresh).


18. The composition for treatment of tumors according to claim 15,comprising: about 9.4% Red Ren Shen (PANAX GINSING); about 5.7% Fu Ling(PORIA COCOS); about 5.7% Bal Zhu (ATRACTYLODES MACROCEPHALA); about6.6% Dang Gui (ANGELIC SINENSIS); about 5.7% Huang Qi (ASTRAGALUSMEMBRANACEUS); about 5.7% Huang Qin (SCUTELLARIA BAICALENSIS); about5.7% Huang Lian (COPTIS CHINENSIS); about 5.7% Gan Cao (GLYCYRRHIZAURALENSIS); about 1.8% Mai Ya (HORDEUM VULGARE); about 6.6% Bai Hua SheShe Cao (HEDYOTIS DIFFUSA); about 4.7% Ban Bian Lian (LOBELIA CHINESISLOUR); about 5.7% Ban Zhi Lian (SCUTELLARIA BARBABA); about 1.8% Shen Qu(MASSA FERMENTATA MEDICALIS); about 5.0% Chai Hu (BUPLEURUMSCORZONERIFOLIUM) about 5.0% Ban Xia (PINELLIA TERNATA); about 5.0% ChenPi (CITRUS RETICULATA); about 5.0% Chuan Lian Zi (MELIA TOOSENDAN);about 4.0% Bai Shao (PAEONIA LACTIFLORA); and about 6.0% Ling Zhi(GANODERMA LUCIDUM).


19. The composition of claim 18 further comprising: about 4.7% Huang Bai(PHELLODRON CHINENSE).


20. The composition of claim 18 further comprising: about 2.0% Jiang(dry or fresh) (ZINGIBER OFFICINALE).